Polynucleotides Explained: Benefits and uses for skin rejuvenation

When it comes to aesthetic medicine, there’s always something new making waves – and right now, polynucleotides are having their big moment. These clever molecules are generating a buzz, and not just because of their unusual origin story. Yes, they’re derived from salmon DNA, and yes, some like to refer to them as salmon sperm treatments.

But don’t let that throw you – behind the quirky nickname is some seriously smart science!

Polynucleotides are long chains of nucleotides, which are the building blocks of DNA and RNA. In the context of skin health, these molecules work like tiny messengers, encouraging your skin to do what it naturally does best: repair, regenerate, and rejuvenate. By stimulating your body’s own collagen and elastin production, they help restore the skin’s youthful structure leading to a smoother, healthier, more radiant complexion.

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What makes Polynucleotides so skin-friendly?

One of the standout qualities of polynucleotides is that they’re biocompatible – which simply means your body recognises them and doesn’t see them as a threat. This is a big deal in aesthetic treatments, because synthetic ingredients that can sometimes irritate or cause reactions, polynucleotides blend seamlessly with your body’s own processes. This makes them particularly suitable for those looking to address a wide range of skin concerns, from fine lines and wrinkles to dullness, dehydration, and uneven skin texture.

Polynucleotides give your skin a gentle nudge in the right direction, using tools it already understands. Whether you’re after an overall skin refresh or targeting specific issues, this treatment is impressively versatile.

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How do Polynucleotides work?

As we age, our bodies start to produce less collagen and elastin – the two proteins that keep our skin firm, plump, and elastic. Essentially, Polynucleotides remind your skin to get back to work. When injected into the skin, they activate fibroblasts which then go on to produce more collagen and elastin. This reawakens your skin’s natural ability to repair itself, and over time, this leads to visible improvements in texture, tone, and firmness.

But that’s not all. Polynucleotides also promote better cellular turnover and enhanced blood flow, both of which are essential for maintaining healthy, glowing skin. They even reduce inflammation and oxidative stress, helping to calm the skin and support long-term skin health.

Another standout benefit is hydration. Polynucleotides have a natural ability to retain moisture, which means they don’t just help your skin look more supple—they actually help it feel more hydrated and comfortable, too.

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So, whether it’s dullness, dryness, or loss of firmness you’re worried about, this treatment doesn’t mask problems, it tackles the issue from the inside out – literally.

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The benefits of Polynucleotides:

Improved skin texture

If your skin feels rough, uneven, or looks a little tired, polynucleotides can help smooth things over. By promoting collagen production and cellular regeneration, they refine the skin’s surface, giving it a softer, more even finish.

Enhanced hydration

Thanks to their moisture-binding properties, polynucleotides boost the skin’s hydration levels. This leads to a healthy, dewy skin while also improving elasticity and comfort, making them especially beneficial for dry or mature skin types.

Reduced fine lines and wrinkles

One of the biggest reasons people seek out polynucleotide treatments is to tackle the early signs of ageing. As collagen and elastin production ramps up, fine lines and wrinkles naturally start to soften. This results in skin that looks smoother and more youthful.

Firmer, more elastic skin

Loss of elasticity is a common concern as we age but polynucleotides help to restore bounce and elasticity by encouraging fibroblast activity and rebuilding the skin’s internal scaffolding – no scalpel required.

Natural radiance

With improved blood flow, hydration, and cellular turnover, many patients notice an overall boost in skin radiance. Your skin looks healthier and more luminous within just a few weeks, even without makeup.

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What to expect from a Polynucleotide treatment

Polynucleotide treatments are typically quick and relatively comfortable. Each session lasts around 30 minutes, and depending on your skin’s needs, a course of 3 to 4 treatments spaced two weeks apart is usually recommended. Maintenance treatments may follow every few months to keep the results going strong.

It’s important to understand that polynucleotide results aren’t instant. Since the treatment works by boosting your body’s natural repair mechanisms, results appear gradually. You can expect to see a difference usually around a few weeks after your first session, with continued improvements for up to 5 months.

As for downtime, it’s minimal. You might experience some light redness, swelling, or bruising at the injection sites, but these usually subside within a day or two. Most people return to their usual activities straight after treatment.

However, it’s important to note that people with seafood allergies should not receive polynucleotide treatments, as they’re derived from fish DNA. Additionally, certain medical conditions, including pregnancy, breastfeeding, autoimmune disorders, and bleeding disorders, may exclude individuals from receiving polynucleotide injections.

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Curious how Polynucleotides compare to other treatments?

At the Anti Wrinkle Clinic, we offer a range of regenerative and injectable skin treatments – and we know it can be tricky to figure out which one is right for your needs. That’s why we’ve put together a dedicated blog post comparing polynucleotides to other popular treatments like Profhilo, Sunekos, and Sculptra. You’ll also find detailed information on our Polynucleotides treatment page, including FAQs and booking options if you’re ready to take the next step.

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Conclusion

Polynucleotides represent a new wave of skin rejuvenation – one that supports your skin from within using safe, natural, and biocompatible ingredients. Rather than offering quick fixes or surface-level tweaks, these treatments work with your body to restore hydration, structure, and radiance over time.

Because they’re derived from natural DNA sources and mimic your body’s own regenerative processes, polynucleotides offer a safe and effective way to support long-term skin health and appearance.

If you’re ready to explore whether this treatment is right for your concerns and goals, we invite you to book a consultation with Dr Yiannis. He’ll guide you through your options and help you build a personalised treatment plan designed exclusively around your skin.