November 19, 2024

Polynucleotides explained: Benefits and uses for skin rejuvenation

Derived from natural sources like salmon DNA, they help improve skin quality by stimulating collagen production.

Polynucleotides are long chains of nucleotides, the building blocks of DNA and RNA, used in skin rejuvenation treatments. Derived from natural sources like salmon DNA, they help improve skin quality by stimulating collagen production. This article explores what polynucleotide treatments are, their benefits, how they work, and what to expect if you consider this option.

Key Takeaways

  • Polynucleotides, derived primarily from salmon DNA, play a significant role in skin rejuvenation by stimulating collagen and elastin production, improving hydration, texture, and reducing fine lines.
  • The treatment process involves a series of minimally invasive injections, typically spaced 2-4 weeks apart, with results lasting up to 6 months, requiring a consultation to determine suitability.
  • Polynucleotide treatments are generally well-tolerated with mild side effects, but individuals with allergies, active infections, or certain medical conditions should consult a healthcare provider before proceeding.

What Are Polynucleotides?

An illustration of polynucleotides, highlighting their structure.

Polynucleotides are fascinating molecules composed of long nucleotide sequences, which are the building blocks of DNA and RNA. These molecules are derived from natural sources, most notably salmon DNA, and play a crucial role in various cellular functions. In aesthetic treatments, polynucleotides stand out for rejuvenating the skin by stimulating collagen production and improving overall skin quality.

Polynucleotide treatments are notable for their biocompatibility, making them well-tolerated and associated with minimal side effects. This makes them a preferred choice for those seeking safe and effective solutions to improve their skin’s appearance.

These treatments tackle various skin concerns, including fine lines, wrinkles, texture, and hydration issues.

How Polynucleotide Treatments Work

A graphical representation of how polynucleotide treatments work.

These treatments trigger the body’s natural production of collagen and elastin, crucial proteins for maintaining skin health and elasticity. Administering polynucleotide injections into the skin stimulates these proteins, resulting in tighter and structurally improved skin. The process resembles giving your skin a fresh start, enhancing its natural repair and renewal abilities to improve skin elasticity and achieve improved skin elasticity.

Additionally, polynucleotides boost skin hydration by increasing the production of essential skin-supporting elements. As a result, your skin not only looks better but also feels more supple and hydrated. Moreover, these treatments promote cellular regeneration, aiding in the repair and renewal of skin cells to maintain healthy, youthful skin.

Involved in biological processes like wound healing and tissue repair, polynucleotides are fundamental for overall skin health. Regular polynucleotide treatments naturally improve skin texture, elasticity, and health over time, providing a holistic approach to rejuvenation.

Benefits of Polynucleotide Treatments

A before and after comparison of skin treated with polynucleotide injections.

Polynucleotide treatments offer numerous benefits, making them a popular choice for overall skin rejuvenation. They significantly enhance skin vitality and health, promoting a youthful appearance. Some of the primary benefits of Polynucleotides are as follows:

  • Detoxifying effect against free radicals and oxidative stress, which contributes to skin breakdown and the appearance of wrinkles.
  • Triggers and improves tissue regeneration by attracting stem cells, which have a strong reparative effect.
  • Restores skin tone and elasticity by producing collagen type I (while Profhilo stimulates type III) and promoting the maturation of fibroblasts into myofibroblasts, resulting in a specific lifting and revitalising effect suitable for all skin types.
  • Increases local vascularisation.
  • Has a moisturizing effect due to its strong water retention capabilities. Its anti-free radical action prolongs the activity of hyaluronic acid, reducing its degradation by around 40%.
  • Helps with contouring and tightening.

What sets polynucleotides (Ameela is the brand of polynucleotides used in our clinic) apart from other skin boosters is their ability to target all tissue layers affected by the aging process, including bone, muscle, and adipose tissue. This unique characteristic makes Polynucleotides an effective treatment option for a wide range of aging-related concerns.

Polynucleotides help protect the skin from free radicals and cellular damage by enhancing the skin's natural defense mechanisms and promoting repair. They act as antioxidants, neutralizing free radicals that cause oxidative stress, which is a key contributor to cellular damage and accelerated aging. By increasing the activity of fibroblasts and supporting the regeneration of new, healthy cells, polynucleotides improve the skin’s resilience and ability to repair itself. This not only slows down visible aging but also strengthens the skin barrier, making it better equipped to resist environmental stressors and maintain overall skin health.

Addressing also key concerns like hydration, texture, and fine lines, polynucleotide treatments offer a comprehensive solution for radiant skin.

Skin Hydration

A key benefit of these treatments is their ability to enhance skin hydration. They boost the skin’s moisture retention, resulting in a more hydrated and plump appearance. Promoting the skin’s moisture retention, polynucleotides contribute to healthier, more resilient skin.

They work synergistically with hyaluronic acid, a common skincare ingredient, to maximize moisture retention. This combination ensures deep hydration, resulting in a noticeable moisturizing effect. This synergy is especially beneficial for dry or sensitive skin, enhancing overall hydration and quality.

Improved Skin Texture

These treatments are highly effective in improving skin texture. By promoting skin cell repair and renewal, they address concerns caused by environmental damage, like sunspots and uneven texture. The result is a smoother complexion that radiates health and vitality, thanks to skin boosters and skin regeneration.

Sun damage commonly affects many, leading to rough texture and discoloration. Polynucleotides combat these effects by refining the skin’s surface and promoting an even tone. Consistent use of polynucleotides significantly improves texture, making the skin look and feel smoother and more youthful.

Reduced Fine Lines and Wrinkles

As we age, fine lines and wrinkles become more prominent, but polynucleotide injections provide a powerful solution. These injections stimulate the body’s natural collagen production, essential for minimizing fine lines and sagging skin. By promoting collagen and elastin production, polynucleotide treatments help maintain skin elasticity and firmness.

The effectiveness of these treatments in reducing wrinkles and fine lines is well-documented. They are particularly beneficial for treating fine lines in delicate areas, such as the under-eye region. By enhancing elasticity and promoting cellular repair, polynucleotides help achieve a more youthful appearance.

Comparison with Other Treatments

A comparison chart of polynucleotide treatments versus other aesthetic treatments.

Comparing polynucleotide treatments with other aesthetic options highlights their unique benefits. Unlike dermal fillers that provide immediate volume, polynucleotides focus on long-term rejuvenation by stimulating collagen production.

Polynucleotides can also be combined with treatments like laser therapy and microneedling to enhance results.

Polynucleotides vs. Hyaluronic Acid Fillers

Polynucleotides and hyaluronic acid fillers serve different purposes for skin rejuvenation. Polynucleotides stimulate the production of collagen and elastin, while hyaluronic acid fillers primarily add volume. This makes polynucleotides ideal for improving overall skin quality, while fillers target specific volume loss areas.

Another key difference is how these treatments work together. Polynucleotides enhance moisture retention, working synergistically with hyaluronic acid to keep skin hydrated and plump. This combination addresses both hydration and structural concerns, providing a comprehensive approach to skin rejuvenation.

Polynucleotides vs. Profhilo

Comparing polynucleotides to Profhilo highlights key differences in composition and targeted concerns. Polynucleotide injections promote cellular repair and regeneration, making them ideal for various skin issues. Profhilo primarily focuses on skin laxity and hydration, offering different benefits.

A notable advantage of polynucleotides is their suitability for treating the sensitive under-eye area. Both treatments have unique advantages, and the choice depends on the specific skin concerns.

Polynucleotides vs. Sunekos

Polynucleotides and Sunekos are both injectable treatments aimed at skin rejuvenation, but they work in distinct ways. Polynucleotides focus on repairing and regenerating the skin at a cellular level, enhancing tissue repair, reducing inflammation, and supporting skin resilience. Sunekos, on the other hand, combines hyaluronic acid with amino acids to stimulate collagen and elastin production, improving skin texture, elasticity, and hydration gradually. While both improve skin quality, Sunekos is ideal for boosting elasticity and radiance, whereas polynucleotides offer deeper repair and resilience, especially for damaged or aging skin.

What is the Ameela brand of polynucleotides and why is Dr Yianni's preference:

Ameela is a brand developed by Amedica, a company with over a decade of experience in the global market for injectable polynucleotide skin treatments. In June 2023, Amedica rebranded its polynucleotide range from Nucleadyn to Ameela, aiming to distinguish its products in a growing market.

The Ameela portfolio comprises three distinct products: Ameela Eyes, Ameela Rejuvenation, and Ameela Face. Each product contains varying concentrations of polynucleotides to address specific treatment areas and skin concerns: Ameela Eyes is formulated for the delicate under-eye region, targeting issues like dark circles and fine lines. Ameela Rejuvenation focuses on overall skin revitalization, improving texture, elasticity and under eye hollow without the need of traditional dermal fillers. Ameela Face is designed for facial treatments, enhancing firmness and reducing signs of aging.

What sets Ameela apart from other brands is its use of highly purified polynucleotides extracted from salmon DNA, which closely resembles human DNA. This similarity ensures high biocompatibility and minimizes the risk of adverse reactions. The purification process removes proteins and hormones, resulting in a product with over 95% pure active substance, free from immunological side effects. This high purity level enhances the safety and efficacy of the treatments, making Ameela a superior choice in the field of skin rejuvenation.  

Treatment Process and Expectations

Knowing the treatment process and expectations is crucial for anyone considering polynucleotide treatments. A course of 3 treatments spaced 2-4 weeks apart, is typically recommended to achieve optimal results.

The effects of polynucleotide injections can last up to 6 months  offering a long-lasting solution for skin rejuvenation.

Consultation and Suitability

A thorough consultation is the initial step to determine if polynucleotide treatments are suitable for you. During this meeting, a qualified professional will assess your skin conditions, medical history, and desired results. This evaluation ensures a treatment plan customized for your unique skin issues and goals.

Consulting a qualified professional helps you understand the potential benefits and risks associated with polynucleotide injections. This step sets realistic expectations and ensures you are a suitable candidate.

Procedure Details

The procedure for polynucleotide treatments is relatively quick, typically taking only a few minutes per area. Polynucleotide injections are minimally invasive and administered into the deep dermis using specific techniques.

A topical anaesthetic is applied before the procedure to ensure patient comfort. This numbing cream alleviates discomfort during injections, making the process smooth and manageable. Detailed pre-treatment instructions are provided to enhance effectiveness.

Aftercare and Recovery

Aftercare is crucial to maximize the benefits of polynucleotide treatments. Patients receive comprehensive aftercare instructions to manage side effects and support healing.

Avoiding heat exposure for 24-48 hours after treatment helps minimize swelling and redness. Proper hydration supports cellular repair and overall recovery. Following these guidelines ensures smooth recovery and enhances the longevity of results.

Side Effects and Safety Considerations

An infographic detailing the side effects and safety considerations of polynucleotide treatments.

Polynucleotide treatments are generally well tolerated, but potential side effects should be noted. Common side effects include temporary redness, swelling, and mild bruising at the injection site. These reactions are typically mild and resolve within a few days.

Though rare, serious side effects can occur. One example is allergic reactions. Patients on blood thinners or immunosuppressive medications should approach polynucleotide treatments with caution and consult their healthcare provider. Individuals with active infections, immunodeficiency, or bleeding disorders should avoid polynucleotide therapy.

Cost of Polynucleotide Treatments

The treatment protocol for this procedure involves an initial course of 3 sessions, each spaced 2 to 4 weeks apart, followed by a maintenance treatment every 5 months to sustain the results. The cost is £900 per area, with each session priced at £300. It’s important to note that the face and eyes are considered separate areas, so treating both areas will cost £1800. This structured approach ensures optimal rejuvenation, with ongoing maintenance to prolong the effects over time.

Who Should Avoid Polynucleotide Treatments?

Polynucleotide treatments are not suitable for everyone, and certain conditions may contraindicate their use. Individuals with allergies to treatment ingredients, especially sea food, should avoid polynucleotide treatments. Active skin infections are also a contraindication for receiving polynucleotide injections.

Additionally, certain medical conditions, including pregnancy, breastfeeding, autoimmune disorders, and bleeding disorders, may exclude individuals from receiving polynucleotide injections. It is essential to consult a healthcare provider to determine if polynucleotide treatments are appropriate for you.

Summary

In conclusion, polynucleotide treatments offer a comprehensive solution for skin rejuvenation, addressing hydration, texture, and fine lines. These treatments are derived from natural sources, making them safe and biocompatible. By stimulating collagen and elastin production, polynucleotide treatments provide long-term improvements in skin health and appearance.

If you’re seeking a holistic approach to skin rejuvenation, polynucleotide treatments might be the answer. Consult a qualified professional to explore this innovative treatment and embark on a journey to radiant, youthful skin.

As a patient at the Anti Wrinkle Clinic, you’ll work with Dr Yiannis to find out which treatment is right for you. Start your journey with Dr Yiannis today.

Frequently Asked Questions

What are polynucleotides?

Polynucleotides are long-chain molecules made up of nucleotide sequences that are essential for cellular functions and may aid in skin rejuvenation. Their natural origins, such as from salmon DNA, highlight their significance in biological processes.

How do polynucleotide treatments work?

Polynucleotide treatments effectively stimulate the body's natural production of collagen and elastin, leading to improved skin hydration, texture, and overall health. This enhances the skin’s appearance and vitality.

What are the benefits of polynucleotide treatments?

Polynucleotide treatments offer improved skin hydration and texture while reducing fine lines and wrinkles, resulting in a more youthful appearance.

How do polynucleotides compare to hyaluronic acid fillers?

Polynucleotides stimulate collagen production and enhance skin quality, while hyaluronic acid fillers primarily provide volume. When used together, they can offer a more comprehensive approach to skin rejuvenation.

Are there any side effects of polynucleotide treatments?

Polynucleotide treatments may cause temporary redness, swelling, and mild bruising, while serious side effects such as allergic reactions are rare. It is essential to monitor for any unexpected reactions during the treatment.

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